NHS Nightingale hospitals in Manchester, Sunderland and Harrogate are being asked to get ready to take patients.
Government advisers say admissions are rising, with more elderly people needing urgent treatment for Covid.
More people are now in hospital with Covid than before restrictions were announced in March.
It comes as a new three-tier system of lockdown rules for England is due to be announced.
Boris Johnson will set out the changes in the Commons on Monday afternoon, before speaking at a Downing Street press conference later.
The Liverpool City Region is expected to face the tightest restrictions under a new three-tier system which will classify regions as being on “medium”, “high” or “very high” alert.
Liverpool recorded 600 cases per 100,000 people in the week ending 6 October. The average for England was 74.
But England’s deputy chief medical officer said the rise in coronavirus cases was now being seen “nationwide” and was not solely a problem for northern England.
Prof Jonathan Van-Tam said the “marked pick-up” in cases that the country was seeing would lead to more deaths and he warned that coronavirus was spreading from younger age groups into the over 60s who are more vulnerable.
Hospitals have not yet reached capacity, but the NHS may have to use some of the temporary critical care Nightingale hospitals if demand continues to rise, say the advisers.
NHS England’s medical director Prof Stephen Powis cautioned that it would take “a number of weeks” before the benefit of any extra measures – such as shutting pubs – would be seen in bringing hospital admissions down.
“In the over-65s – particularly the over-85s – we are seeing steep rises in the numbers of people being admitted to hospital so the claim that the elderly can somehow be fenced off from risk is wishful thinking,” he said.
He said NHS staff working in the parts of England with the highest Covid rates would be offered regular tests to check if they had the virus.
Dr Jane Eddleston, medical lead in Greater Manchester, urged the public to “respect” the virus due to the “extremely serious” consequences it has for some patients.
She told the press briefing: “The North West has about 40% of all Covid cases at the moment and this is proving very challenging for us.”
Prof Van-Tam reminded people how the virus spreads – in closed spaces, crowded places and between close contacts.
On Sunday, 12,872 people in the UK were reported to have tested positive for coronavirus – some 2,294 fewer than on Saturday.
There were a further 65 deaths – down from 81 on Saturday.