The coronavirus mutation causing concern in Denmark has arisen before in mink, scientists have revealed.
The mutated virus has been detected retrospectively in mink at a farm in the Netherlands, but it did not spread to humans, said a leading Dutch expert.
Denmark is culling all its farmed mink due to concerns about a coronavirus strain that has infected a dozen people.
There are fears the mutated virus could undermine vaccine development.
The genetic change is in a part of the virus known as the spike protein, which is important in immunity, and a target for future vaccines and treatments.
The Danish genome sequences were recently released on a public database, allowing scientists in other countries to look for evidence of the mutation.
Prof Wim van der Poel, a veterinary expert at Wageningen University, said analysis of genetic data from the Netherlands revealed one previous case of the mutation at a mink farm there.
He told BBC News: “We have once seen a mutant virus with a comparable mutation in the spike protein encoding region, in mink in the Netherlands, but this mutant did not spread to humans and the mink of the involved farm were culled.”
The Netherlands launched a widespread cull of mink after signs, in a small number of cases, that humans had picked up coronavirus from mink.
The genetic data from Denmark was released on an international database a few days ago, with some scientists questioning why it had not been released sooner.
“I think that it is most disappointing that the data have only just reached the light of day,” said Prof James Wood, head of the department of veterinary medicine at the University of Cambridge, UK.
He said the genetic changes needed careful evaluation, as reports from Denmark suggested an effect on immunity. “This may be what triggered the enhanced quarantine measures for travellers from Denmark. But far more careful evaluation is urgently needed.”
Mink farming required “enhanced biosecurity (or suspension) at this time”, he added.
It is normal for viruses to change over time and accumulate mutations, but experts are particularly concerned when viruses pass between humans and animals.
Prof Dirk Pfeiffer, of the Royal Veterinary College in London, said while mutations in viruses happen all the time as they spread, the question is whether these change the characteristics of the virus.
“At this stage, it seems to be that there may be issues with vaccine effectiveness, but this is still unclear,” he said.
Effective surveillance is needed to detect emergence of new pathogens early, and then have an effective way of responding, he added.
Six countries have reported coronavirus outbreaks at mink farms: the Netherlands, Denmark, Spain, Sweden, Italy and the US.
The European Centre for Disease Prevention and Control, an agency of the European Union, has said it will publish risk assessments on the spread of Sars-CoV-2 in mink farms this week.
It remains to be seen if the Danish mutation in the Sars-CoV-2 virus (which causes Covid-19) will be detected in other countries with mink farms. The outbreak of this mutated variant has become known as “cluster 5”.
In Sweden, there have been outbreaks at mink farms in the southeast part of the country. Scientists reported that the genetic mutation found in Danish mink had not been detected so far.
Follow Helen on Twitter.